Efektifitas Ekstrak Cair Pemanis Alami Daun Stevia (Rebudiana Bertoni) Terhadap Kadar Gula Darah Sewaktu
Keywords:
stevia, pemanis alami, gula, kadar gula darah sewaktuAbstract
Diabetes melitus (DM) merupakan masalah kesehatan global dengan prevalensi yang terus meningkat, salah satunya dipicu oleh tingginya konsumsi gula sederhana. Stevia (Stevia rebaudiana Bertoni) merupakan pemanis alami rendah kalori yang berpotensi menjadi alternatif pengganti gula pasir. Penelitian ini bertujuan menganalisis efektivitas ekstrak cair stevia terhadap kadar gula darah sewaktu dibandingkan dengan gula pasir. Penelitian menggunakan desain crossover kuasi-eksperimental pada 88 mahasiswa Jurusan Gizi Politeknik Kementerian Kesehatan Manado. Responden menerima intervensi berupa ekstrak cair stevia dan larutan gula pasir pada waktu yang berbeda. Konsumsi ekstrak cair stevia tidak menyebabkan perubahan signifikan kadar gula darah sewaktu dibandingkan kondisi sebelum intervensi (104,64 menjadi 102,98 mg/dL; p=0,129). Sebaliknya, konsumsi larutan gula pasir meningkatkan kadar gula darah sewaktu secara signifikan (95,90 menjadi 110,03 mg/dL; p<0,001). Kadar gula darah sewaktu setelah konsumsi stevia juga lebih rendah dibandingkan kadar gula darah sewaktu setelah konsumsi gula pasir. Sehingga disimpulkan bahwa ekstrak cair stevia tidak meningkatkan kadar gula darah sewaktu
References
Lestari, Zulkarnain, Sijid SA. Diabetes Melitus: Review Etiologi, Patofisiologi, Gejala, Penyebab, Cara Pemeriksaan, Cara Pengobatan dan Cara Pencegahan. UIN Alauddin Makassar. 2021;(November):237–41.
IDF. DIABETES ATLAS, Ninth edition 2019. 2019.
Kementerian Kesehatan RI. Laporan Nasional Riskesdas. Badan Penelitian dan Pengembangan Kesehatan. 2018;
Kementerian Kesehatan RI. Survei Kesehatan Indonesia Dalam Angka. Badan Kebijakan Pembangunan Kesehatan. 2023;
Zendrato VN, Harahap HS, Silalahi NW, Panjaitan SS, Susilo RP. Konsumsi Indeks Glikemik Tinggi pada Kejadian Penyakit Diabetes Melitus Tipe 2. Jurnal Kesehatan Masyarakat Mulawarman (JKMM). 2025;7(1):1.
Masoumi SJ, Ranjbar S, Keshavarz V. The Effectiveness of Stevia in Diabetes Mellitus: A Review. International Journal of Nutrition Sciences. 2020;5(2):45–9.
Wirwan S. Metode Penelitian Untuk Tenaga Kesehatan. Thema Publishing; 2022.
Widyasanti A, Klarasitadewi A, Nurjanah S. Pengaruh Rasio Bahan-Pelarut Dan Lama Terhadap Karakteristik Fisikokimia Ekstrak Cair Daun Stevia (Stevia Rebaudiana Bertoni) The Effects Of Solid-Solvent Ratio And Extraction Time To The Physicochemical Characteristics Of Stevia Leaf Extract. 2022;12(2):86–95.
Pan Q, Zhang L, Gu A, Yu D, Wang X, Zhou Y, et al. The Absorption of Needle-Free Insulin Aspart Through Jet Injector in Different Body Parts of Healthy Individuals. Frontiers in Endocrinology. 2022;13(April):1–8.
Farhat G, Berset V, Moore L. Effects of Stevia Extract on Postprandial Glucose Response, Satiety and Energy Intake: A Three-Arm Crossover Trial. Nutrients. 2019;11(12).
Stamataki NS, Crooks B, Ahmed A, McLaughlin JT. Effects of the daily consumption of stevia on glucose homeostasis, body weight, and energy intake: A randomised open-label 12-week trial in healthy adults. Nutrients. 2020;12(10):1–16.
Adriana Monserrath Orellana-Paucar. Steviol Glycosides from Stevia rebaudiana: An Updated Overview of Their Sweetening Activity, Pharmacological Properties, and Safety Aspects. Molecules. 2023;28(3).
Zare M, Zeinalabedini M, Azadbakht L, Ebrahimpour-Koujan S, Ebrahimpour-Koujan S, Bellissimo N, et al. Effect of stevia on blood glucose and HbA1C: A meta-analysis. Vol. 18, Diabetes and Metabolic Syndrome: Clinical Research and Reviews. 2024.
Bai X, Qu H, Zhang J, Li L, Zhang C, Li S, et al. Effect of steviol glycosides as natural sweeteners on glucose metabolism in adult participants. Vol. 15, Food and Function. 2024.
Almiron-Roig E, Navas-Carretero S, Castelnuovo G, Kjølbæk L, Romo-Hualde A, Normand M, et al. Impact of acute consumption of beverages containing plant-based or alternative sweetener blends on postprandial appetite, food intake, metabolism, and gastro-intestinal symptoms: Results of the SWEET beverages trial. Appetite. 2023;184.
Greyling A, Appleton KM, Raben A, Mela DJ. Acute glycemic and insulinemic effects of low-energy sweeteners: A systematic review and meta-analysis of randomized controlled trials. Vol. 112, American Journal of Clinical Nutrition. 2020.
Zheng Y, Si Y, Li X, Jin S, Chen Y, Chen X. Sweet-Tasting Plants in regulating glucose metabolism: Mechanisms, applications and future directions. Journal of Functional Foods. 2025;135.
Peteliuk V, Rybchuk L, Bayliak M, Storey KB, Lushchak O. Natural Sweetener Stevia Rebaudiana: Functionalities, Health Benefits and Potential Risks. EXCLI Journal. 2021;20:1412–30.
Ajami M, Seyfi M, Abdollah Pouri Hosseini F, Naseri P, Velayati A, Mahmoudnia F, et al. Effects of stevia on glycemic and lipid profile of type 2 diabetic patients: A randomized controlled trial. Avicenna journal of phytomedicine. 2020;10(2):118–27.
Ludwig DS. Dietary Carbohydrates: Role of Quality And Quantity In Chronic Disease. BMJ. 2018;361.
WHO. Guideline: Sugars Intake For Adults and Children. Vol. 57, World Health Organization. 2018. 1716–1722 p.
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Elfredo Halawa, Nivalayanti Gagu, Olga Lieke Paruntu, Mayangsari Ante Laudea, Romiza Arika
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
This work is licensed under CC BY-NC-SA 4.0
- Author is the copyright owner of all materials published on this website.
- The formal legal provisions for access to digital articles of this electronic journal are subject to the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license (CC BY-NC-SA 4.0), which means that MEDIA GIZI ILMIAH INDONESIA journal and readers reserve the right to save, transmit media / format, manage in database, maintain, and publish articles as long as it continues to include the name of the Author.
- Published electronic manuscripts are open access for educational, research and library purposes. In addition to these objectives, the editorial board shall not be liable for violations of copyright law.
